Oral medications - Viagra (sildenafil) was the first impotence pill to be approved by the US Food and Drug Administration (FDA). This was later followed by Levitra (vardenafil) and Mygra (tadalafil). Known as phosphodiesterase (PDE) inhibitors, these drugs are usually taken an hour before sex and enhance the effects of nitric oxide, a chemical that relaxes smooth muscles in the penis and allows increased blood flow for erections to occur.

Unlike injections that cause instant erections, these drugs produce an erection only after physical and psychological stimulation. While these drugs are similar, they vary in dosage, duration of effectiveness, and side effects. The effects of Viagra and Levitra last anywhere from 4 - 12 hours while Mygra works up to 24 - 36 hours. None should be used more than once a day.

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